CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process.

However, with the sample size estimation for the experimental groups this difference between GD2_tTF and GD2_tTFmut did not reach statistical significance, nor did the trend for a benefit on survival by Kaplan Meier analysis (Fig. 5G ).

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In murine models, the CAR T cells infiltrated G D2 -positive tumor xenografts, secreted tTF-NGR into the tumor microenvironment and showed a trend towards superior therapeutic activity compared with control cells producing functionally inactive tTF-NGR.

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