The effect of tacrolimus conversion from immediate- to extended-release formulation on renal function in renal transplant patients: a meta-analysis.

In patients with the tacrolimus dose after conversion ≤4.0 mg/d, only one study reported eGFR, and eGFR exhibited an increasing trend after tacrolimus conversion compared to before conversion but did not reach statistical significance (MD (95% CI): 6.50 (0.10, 12.90) mL/min/1.73 m 2 , p = 0.05).

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The pooled analysis suggested that eGFR only showed a trend to increase after conversion versus before conversion in renal transplant patients (MD (95% CI): 2.21 (−1.62, 6.03) mL/min/1.73 m 2 , p = 0.26) ( Figure 2B ) but without statistical significance. 3.4 Subgroup analysis for Scr and eGFR Subgroup analysis on Scr was conducted based on the follow-up duration.

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The pooled analysis disclosed that Scr showed a decreasing trend after tacrolimus conversion versus before conversion but did not achieve statistical significance (MD (95% CI): −9.82 (−20.94, 1.30) μmol/L, p = 0.08).

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In patients with the tacrolimus dose after conversion ≤4.0 mg/d, only one study reported eGFR, and eGFR exhibited an increasing trend after tacrolimus conversion compared to before conversion but did not reach statistical significance (MD (95% CI): 6.50 (0.10, 12.90) mL/min/1.73 m 2 , p = 0.05).

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