Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila.

According to the IASL system, liver fibrosis was moderate (with occasional septae) in 62.5% (5/8) of mice in the HFHCC group, while only 25% (2/8) of mice in both 2% and 4% groups exhibited liver fibrosis (Pearson’s χ 2 p < 0.05), reflected also by the Sirius red-stained area, which, however, did not reach statistical significance ( Figure 4 M).

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α diversity analysis showed a trend toward a lower Shannon index, indicating the expansion and a certain degree of dominance of some species in terms of abundance ( Figure 5 B).

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