Non-canonical amino acid incorporation into AAV5 capsid enhances lung transduction in mice.

31 Following this localized treatment regimen ( Figure 5 A), 374NAEK-AAV5 also outperformed the other vectors to target the lung, reaching 3- and 6-fold higher transgene EGFP expression than rAAV5 at mRNA and protein levels, respectively, although difference in transgene DNA abundance among all vectors did not reach statistical significance ( Figure 5 B).

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In addition, 444NAEK-AAV5 and 539NAEK-AAV5 also showed a trend of higher transduction than rAAV5 in HEK293 and A549 cells ( Figure 3 ).

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