Intrauterine Growth and Offspring Neurodevelopmental Traits: A Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa).

Although not passing the strict multiple-testing correction threshold ( P < .005), in the negative control analyses (ie, paternal dyads) (eTable 9 in Supplement 2 ), paternal allele scores showed a trend of positive associations with various offspring NDDs ( P < .05; F1 and SCQ-full at 8 years: β = 1.99E-03, SE = 8.75E-04; M2 and SCQ-RRB at 8 years: β = 3.65E-03, SE = 1.32E-03; M3 and SCQ-RRB at 8 years: β = 5.50E-03, SE = 2.02E-03; F1 and SCQ-SCI at 8 years: β = 2.02E-03, SE = 8.64E-04; M2 and ASQ-LANG at 3 years: β = 2.05E-03, SE = 1.15E-03; and M2 and Children's Communication Checklist–Short Scale at 8 years: β = 3.35E-03, SE = 1.63E-03).

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Similar patterns of results were observed in the parent-offspring trio analyses (eTable 8 in Supplement 2 [ie, 2 nominally significant associations between maternal allele scores and NDDs]) ( P < .05; M1 and SCQ-RRB at 8 years: β = 1.73E-03, SE = 8.08E-04; and M2 and SCQ-SCI at 8 years: β = 3.31E-03, SE = 1.46E-03), and there was evidence for association between offspring scores and NDDs ( P < .05; M1 and SCQ-RRB at 8 years: β = −

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