Phytotherapy (BNO 1045) of Acute Lower Uncomplicated Urinary Tract Infection in Women Normalizes Local Host Responses.

Urol Int · 2023 · PMC10614491 · PMID 37544300

Europe PMC DOI

hedged sentences

0.0551

closest p · 1.1× alpha

0.0551

boldest claim

The sentences

showed a trendp = 0.0551so close (0.05 < p ≤ 0.1)

BNO 1045 treatment decreased urine IL-8 significantly ( p = 0.0142) and showed a trend toward reduction of urine IL-6 ( p = 0.0551).

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did not reach statistical significanceno p-value reported

For IL-6, the decrease was statistically significant in the fosfomycin treatment arm while the decrease under BNO 1045 treatment did not reach statistical significance, indicating that there are potential different mechanisms of protection of the two drugs.

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highly significantno p-value reported

In a combined analysis of the two study arms, treatment resulted in a highly significant reduction of urine cytokine concentrations ( Fig. 1 , 2 ).

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