Primary breast tumor induced extracellular matrix remodeling in premetastatic lungs.

Consistent with the corresponding mRNA expression results, collagen-1 showed a trend of decreased expression in the lungs of metastatic breast tumor-bearing mice, especially in large tumors (Supplementary Figure 5 ).

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For P4HA2, changes in expression levels did not reach significance, but MCF7 conditioned lung fibroblasts were trending towards significance for downregulation in P4HA2 as compared to MCF12A conditioned lung fibroblasts (Fig. 1 C).

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