Comparative analysis of the impact of 40 adenovirus types on dendritic cell activation and CD8⁺ T cell proliferation capacity for the identification of favorable immunization vector candidates.

Compared to the unstimulated control, HAdV transduction resulted in a substantial increase in the concentrations of most cytokines, with the most pronounced effects observed for IFN-α ( Figures 3A, B ) and IFN-β ( Figure 3A ), which showed a clear trend toward strong induction by all HAdV types and statistically significant increases by most species D HAdV types.

also in 19,460 other papers

Expression of the inhibitory molecule PD-L2, on the other hand, was not as strongly affected and was significantly upregulated only by HAdV-B7, -B34, -C1, and -D26, whereas the expression showed a strong trend toward a decrease after transduction with other HAdV types such as HAdV-A18, -B21, -B50, -D17 and -D74.

also in 5,725 other papers