The CALIPR framework for highly accelerated myelin water imaging with improved precision and sensitivity.

MWF values reported in literature show a clear trend of decreasing brain MWF between the posterior internal capsule, splenium of the corpus callosum (CC), genu of the CC, all WM, and all GM, as well as decreasing spinal cord MWF between the DC, WM, LCST, and GM ( 43 ).

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However, given that they constitute two weakly significant results out of the 42 two-sided one-sample t tests performed (MWF and IET2 in 16 brain and 5 cord ROIs), these results are likely spurious and would not survive a correction for multiple comparisons.

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