Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice.

Mice with BAT MR deficiency also demonstrated a decreasing trend of energy metabolism, aggravated eWAT inflammation, and hepatic steatosis.

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Meanwhile, the expression of genes related to lipolysis, including HSL and ATGL , significantly decreased or showed a strong trend of decrease in livers of BMRKO-HFD mice ( Fig. 6 E).

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BMRKO-HFD mice also manifested significantly increased liver weights and hepatic lipid accumulation, an increasing trend of genes related to lipogenesis and lipid uptake, and significantly decreased genes related to lipolytic and fatty acid oxidation in the liver.

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BAT of BMRKO-HFD mice showed an overall trend of decrease in the expression of genes related to fatty acid metabolism, including Acot1 , Acot4 , Acsm3 , Hsd11β1 , Ehhadh , Ucp3 , Slc27a2 , Dagla , and Slc22a5 ( Fig. 4 B).

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Results of RT-qPCR showed that the expression of Acsm3 , Slc27a2 , and Ucp3 significantly decreased in BAT of BMRKO-HFD mice compared with LC-HFD mice, although the decrease of Acot1 did not reach statistical significance ( Fig. 4 G).

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