Microglia activation in periplaque white matter in multiple sclerosis depends on age and lesion type, but does not correlate with oligodendroglial loss.

A similar pattern was observed for PPWM2 and PPWM3; however, the differences did not reach statistical significance (Supplementary Fig.

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Female MS patients showed a trend to higher cell density of HLA-DR-positive microglia in PPWM1, PPWM2, and PPWM3 compared with male MS individuals; however, only the difference between female controls and PPWM1 from female MS patients reached statistical significance (Fig. 2 e).

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