The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties.

Although in heterozygous patients the presence of R232 can compensate for the hypomorphic H232 allele, we highlighted a nearly statistically significant difference in the overall survival of the patients carrying R232 in the homozygous combination with increased survival, compared to the heterozygous H232/R232 patients.

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Beyond the overall survival, Kaplan Meier curves showed a trend of nearly statistically significant divergence at 90 versus 50 weeks (Fig. 10 ), deserving further investigation.

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