Low-intensity pulsed ultrasound alleviates doxorubicin-induced cardiotoxicity via inhibition of S100a8/a9-mediated cardiac recruitment of neutrophils.

LIPUS treatment significantly inhibited the infiltration of leukocytes and neutrophils in the heart and showed a trend to decrease monocytes in the DOX‐LIPUS group (Figure 5a–d ).

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Mice in both DOX‐Sham and DOX‐LIPUS groups tended to have lower heart weight/body weight ratios compared to those in the control groups, although the differences did not reach statistical significance (Figure 1d ).

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