Pneumococcal infections in children with sickle cell disease before and after pneumococcal conjugate vaccines.

However, because the study was underpowered and did not reach statistical significance, 10 routine use of penicillin prophylaxis in those aged ≥5 years was not recommended. 11 After institution of penicillin prophylaxis, both adherence 12 and the emergence of antibiotic resistance 13 presented challenges to this IPD preventive strategy.

also in 75,868 other papers

Strength of association was defined as significant at an α level <.001 and approaching significance at an α level <.050 to .001 (statistical package, SAS 9.4, Cary, NC).

also in 1,619 other papers