Effect of herbal extracts and Saroglitazar on high-fat diet-induced obesity, insulin resistance, dyslipidemia, and hepatic lipidome in C57BL/6J mice.

Heliyon · 2023 · PMC10663915 · PMID 38027691

Europe PMC DOI

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an increasing trendno p-value reported

2 C), demonstrated an increasing trend in the HFD group (approximately 2.4-fold) and in all the treated groups when compared to the control group.

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showed a trendno p-value reported

Both Saroglitazar and TC + PL treatment showed a trend of decreased PPAR-γ expression.

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a decreasing trendno p-value reported

GG and WS also showed a decreasing trend in the steatosis score compared to the HFD group ( Fig. 3 B).

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did not reach statistical significanceno p-value reported

Saroglitazar treatment for 12 weeks led to a reduction in plasma TG levels compared to the control and HFD-fed mice, although these changes did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.