Multifaceted Tissue-Protective Functions of Polyvalent Immunoglobulin Preparations in Severe Infections—Interactions with Neutrophils, Complement, and Coagulation Pathways

Biomedicines · 2023 · PMC10669904

Europe PMC

hedged sentences

0.0960

closest p · 1.9× alpha

0.0960

boldest claim

The sentences

showed a trendp = 0.096so close (0.05 < p ≤ 0.1)

A larger randomized, controlled clinical trial in patients with severe COVID-19 treated with IgM/IgA-enriched Ig preparations showed a trend towards a reduced composite deterioration/mortality rate ( p = 0.096) when treatment was started before invasive mechanical ventilation and before respiratory dysfunction and coagulopathy had progressed into advanced stages [ 143 ].

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a clear trendno p-value reported

Several small clinical studies have shown a clear trend toward a decreased number of ventilator days, faster recovery, and/or shorter hospitalization times when Ig preparations were used.

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