However, CSF NfL levels showed a tendency to increase but the change did not reach statistical significance ( Fig. 3E ).
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Safety and Clinical Effects of a Muse Cell-Based Product in Patients With Amyotrophic Lateral Sclerosis: Results of a Phase 2 Clinical Trial.
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However, the rate of change in the ALSFRS-R scores showed a trend toward improvement at 12 months post-treatment compared with that at 3 months pre-CL2020 administration; however, the difference was not statistically significant ( Fig. 2 , pre-treatment: β = −0.47 vs. post-treatment: β = −0.25, P = 0.096).
The change in the %FVC was maintained in two patients and showed a decreasing trend in three patients.