Impact of operator expertise on transperineal free-hand mpMRI-fusion-targeted biopsies under local anaesthesia for prostate cancer diagnosis: a multicenter prospective learning curve.

Procedure duration A significant trend toward a shorter procedure duration is visible across consecutive patients groups for Centre 2 and for Operators 1, 2, 3, whilst Operator 4 shows a borderline p value (Supplementary Tables 1, 4, 5).

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Operator 3 approaches statistical significance around 50 procedures, whilst for Operator 1, no change from linear trend is detected. csCDR-T Analysing consecutive patients groups, a significant trend for improved csCDR-T was observed only for Centre 2 (Supplementary Table 1).

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In multivariable analysis, experience did not reach statistical significance as a predictor of csCDR-T at a per-operator level; a visual trend might be detected in Operator 4 learning curve (Fig. 2 ).

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