IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial.

Nat Med · 2023 · PMC10719089 · PMID 37957373

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did not reach statistical significanceno p-value reported

Complement showed a similar trend of downregulation but did not reach statistical significance.

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showed a trendno p-value reported

Genes that showed a trend of downregulation included classic inflammatory markers, such as IFN-γ (IFNG), IL-8 (CXCL8), IL-1β (IL1B) and NLRP3, as well as CXCL13 and TLR2.

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