SARS-CoV-2 mRNA vaccination-induced immunological memory in human nonlymphoid and lymphoid tissues.

As a common motif, nonlymphoid (liver, kidney tumor, lung) but not lymphoid (bone marrow, spleen) tissues were characterized by significantly elevated frequencies (or a clear trend thereof in the case of lung) of spike-specific CD4 + T cells over those quantified in blood ( Figure 1G ).

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Individuals with cellular responses in peripheral blood showed a trend toward an elevated rate of specific IgG responses over cellular nonresponders ( Figure 1E ).

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