The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review.

Ann Surg Open · 2023 · PMC10735087 · PMID 38144501

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hedged sentences

0.0570

closest p · 1.1× alpha

0.2300

boldest claim

The sentences

did not reach statistical significanceP = 0.057so close (0.05 < p ≤ 0.1)

Pihl et al stated that the presence of enlarged negative LN (>4.5 mm) tended to be associated with longer survival in stage II CRC, but this did not reach statistical significance (79% vs 86%, P = 0.057). 24 Murphy et al defined LN ≥4 mm as large and showed a significant difference in survival in stage II CRC in favor of patients with large LNneg (73.3% vs 88.0%, P = 0.0015). 26 The 2 remaining studies by Märkl and colleagues, 21 , 27 investigating colon cancer without LN metastasis used a cutoff value of >5 mm for large LN.

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showed a trendP = 0.072so close (0.05 < p ≤ 0.1)

They also showed a trend toward lower chance of progressive disease in the LN5High group [1 out of 28 (LN5high) vs 17 out of 69 (LN5low); P = 0.072).

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a nonsignificant trendP = 0.230not close (p > 0.1)

Survival analysis of the 3 groups showed a nonsignificant trend toward shorter median overall survival in de LN5vl group compared with both other groups (71 months vs 76 months, P = 0.230).

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