Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks.

For the B2 outcome, the IVW method yielded a marginally significant p-value (p=0.023) for the number of cigarettes smoked per day, a finding corroborated by the MR-PRESSO (p=0.025 pre-outlier correction; p=0.029 post-outlier correction; S10 – S13 Figs and S20 Table ) [ 63 – 67 ].

also in 6,545 other papers

In the UKB cohort, we observed a marked trend between the lowest quartile (n = 522) and the highest quartile (n = 735).

also in 122 other papers

Other signals of metabolic and cardiovascular disorders (e.g., hypertension) were attenuated yet remained nominally significant ( Fig 2C and S4 Table ).

also in 1,922 other papers