a clear trendp = 0.086
35/159, 22.0%, p = 0.002), and alopecia ( p = 0.001), while other symptoms, such as exertional dyspnoea, did not reach statistical significance, albeit showing a clear trend towards higher frequency in female patients compared to male patients (103/159, 64.8% vs. 87/159, 54.7%, respectively p = 0.086).