The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial.

Am J Respir Crit Care Med · 2023 · PMC10765395 · PMID 37812772

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

showed a trendP = 0.056so close (0.05 < p ≤ 0.1)

However, the PROMIS sleep disturbance scale showed a trend toward increasing (i.e., worsening) with Ato75 compared with placebo ( P = 0.056).

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did not reach statistical significanceno p-value reported

Improvement in AHI 4 and other respiratory parameters with AD109 occurred during NREM and REM sleep, although the latter did not reach statistical significance versus placebo, as well as during supine and lateral sleep.

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