Transcriptionally, FGF-8b supplementation showed a clear trend of downregulation for the adipogenic markers Pparg, Fabp4, Adipoq, and Lep ( Fig. 2 D ).
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Fibroblast growth factor 8b (FGF-8b) enhances myogenesis and inhibits adipogenesis in rotator cuff muscle cell populations in vitro.
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Transcriptionally, the expression of Pax7 in the + FGF8 group showed a trend of upregulation but did not show a statistically significant change compared to the − FGF8 control ( Fig. 6 I ).