Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease.

Transl Psychiatry · 2024 · PMC10770135 · PMID 38182581

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did not reach statistical significancep = 0.40not close (p > 0.1)

Neither CSF nor serum ANGPT-2 correlated with age: despite a trend towards a rise in CSF ANGPT-2 with age, the correlations did not reach statistical significance ( p = 0.40, r = 0.06) (Supplementary Fig. 1 ) Discussion In this study, we show elevated CSF ANGPT-2 levels in individuals with CSF biomarker positivity for AD, based on established cut-off values for t -tau, p -tau181 and Aβ42 [ 26 ], which correlated with CSF t -tau and p -tau181, and with markers of pericyte injury (sPDGFRβ) and BBB leakiness (CSF fibrinogen).

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showed a trendno p-value reported

Serum ANGPT-2 showed a trend towards positive correlation with both CSF ANGPT-2 and the CSF/serum albumin ratio.

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