Exploration of cancer associated fibroblasts phenotypes in the tumor microenvironment of classical and pleomorphic Invasive Lobular Carcinoma.

Front Oncol · 2023 · PMC10772146 · PMID 38192631

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showed a trendno p-value reported

In addition, there were two other phenotypes namely A-SMA+/Thy-1+(closer to tumor cells in classic ILC) and FAP+/S-100+ (closer to tumor cells in pleomorphic ILC), which showed a trend of significance ( Supplementary Table 4 and Figures 5A, B , 6A, B ).

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approaching significanceno p-value reported

In the tumoral compartment, although a statistically significant difference in the density of CAFs was found only in A-SMA+S100+ CAFs (being higher in classic ILC), an “approaching significance” or a trend was seen with Thy-1+, Total FAP+, FAP+ only and FAP+S100+ CAFs being higher in pleomorphic subtype.

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