Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity.

These features were accompanied by a tendency of reduced total hepatic lipid content (although the results did not reach statistical significance, p = 0.09; Figure 4 E) and a reduction in the expression of genes involved in de novo lipogenesis ( Acc1 , p = 0.0081; Fasn , p = 0.030; Scd1 , p = 0.017; Figure 4 F).

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In fact, we found a significant trend toward higher plasma levels in the recipient mice with higher circulating histidine levels of the donor (p Mann-Kendall = 0.034) ( Figure S5 B).

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