Carcinoembryonic antigen-expressing oncolytic measles virus derivative in recurrent glioblastoma: a phase 1 trial.

CEA levels There was a slight increase in CEA levels from pre- to post treatment: 0.127 ng/ml (95% CI: −0.093, 0.348), but this did not reach statistical significance (paired t test P = 0.244).

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Of importance, there was a strong trend supporting a reverse correlation between DLDA score and CD8 lymphocytic infiltration in posttreatment samples suggesting that viral replication plays an important role in the observed posttreatment remodeling of tumor microenvironment.

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