The modified Polsby-Popper score, a novel quantitative histomorphological biomarker and its potential to predict lymph node positivity and cancer-specific survival in oral tongue squamous cell carcinoma.

Although not statistically significant, an improved RFS could be observed in the group with an MPP score <4.2 ( p = 0.244), and patients who underwent upfront or delayed additional resection of the primary tumor site because of close resection margins assessed intraoperatively or after evaluating the FFPE tissue specimen exhibited a more favorable RFS, although the results failed to reach statistical significance ( p = 0.264).

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While the MPP score did not reach statistical significance, the other three covariates were significantly associated with the outcome of interest (Figure 7B ). 3.3.5.

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