Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low <i>MGMT</i> expression.

The dysfunction scores, which reflect the degree of T cell dysfunction, were slightly higher in MGMT-H tumors compared to MGMT-L tumors, although the difference did not reach statistical significance (p = 0.405).

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Although statistical significance was not reached, GSEA analysis also showed a trend of more activated immunological phenotypes in MGMT-H tumors ( Figures 6D, E ).

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