Microbiota-mediated effects of Parkinson's disease medications on Parkinsonian non-motor symptoms in male transgenic mice.

However, two genera within Cluster A, Anaeroplasma and Dorea , showed a strong trend toward correlation with transit time in control mice alone ( P = 0.05 for both; Fig.

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Although this group showed a trend for decreased fecal water content ( P = 0.09; Fig. 1C ), and slightly increased total bacterial load in the jejunum ( P = 0.09; Fig. 1D ) and ileum ( P < 0.05; Fig. 1E ), overall GI function seemed to be improved due to the strength of the effect on GI transit.

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While transit time showed a highly significant correlation with both clusters, inspection of the correlation plots (Fig.

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