The fragile X locus is prone to spontaneous DNA damage that is preferentially repaired by nonhomologous end-joining to preserve genome integrity.

Cells treated with both FdU and A-196 also showed a trend toward a decrease in the number of duplications but this did not reach statistical significance (two-tailed p value = 0.09 for GM07294 and 0.24 for GM04025 using the Fisher’s exact test, Figure 3 B).

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