Microglial inhibition alleviates alpha-synuclein propagation and neurodegeneration in Parkinson's disease mouse model.

At 14 dpi, we observed a decreasing tendency in the soluble and insoluble αSyn contents of the whole brain in PLX5622-treated mice compared to vehicle-treated mice, although the differences did not reach statistical significance (Supplementary Fig. 7b–e ).

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Figure 2b showed a trend of increasing pSyn accumulation in the ipsilateral striatum over time in all three mice groups.

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