Elevated matrix Metalloproteinase-9 associated with reduced cerebellar perineuronal nets in female mice with toxoplasmosis.

4 B, GSK-3β phosphorylation at serine-9 decreased significantly in MAG1-high mice (t (8) = 3.141, P = 0.0138), while GSK-3α phosphorylation at serine 21 showed a trend toward decrease (t (8) = 1.993, P = 0.0814). 3.5 Elevated cerebellar expression of MMP-9, especially in the purkinje cells Since increased MMP-9 levels were only found in the MAG1-high mice, we immunostained brain sections of this group with anti-MMP-9 antibodies.

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The association was supported by a negative trend between MMP-9 and aggrecan expression, a core component of PNNs.

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