Causal association between genetically predicted circulating immune cell counts and frailty: a two-sample Mendelian randomization study.

However, this trend did not reach statistical significance (all P>0.05).

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The UVMR results showed a trend towards an increased FI in total leukocyte count (β = 0.016, 95% CI, –0.003–0.0035), neutrophil count (β = 0.019, 95% CI, 0.019–0.04), and basophil count (β = 0.009, 95% CI, –0.021–0.039), but this trend was not statistically significant in the IVW and sensitivity analyses.

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