Antimicrobial consumption in an acute NHS Trust during the COVID-19 pandemic: intervention time series analysis.

19 , 42 Our study showed a trend in antibiotic consumption in three waves in England and after introducing the NICE guideline in May 2020, 43 highlighting the value of studying the pandemic impact on antimicrobial consumption per individual wave.

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Antibiotics used in respiratory tract infection (RTI) The most frequently prescribed RTI antibiotics, including clarithromycin, levofloxacin, piperacillin/tazobactam, co-amoxiclav, doxycycline and amoxicillin showed a decreasing trend in wave 1.

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Levofloxacin, azithromycin, doxycycline and amoxicillin showed a slight decrease in consumption; clarithromycin showed a decrease from 92.5 to 78.0 DDDs per 1000 OBDs ( P = 0.9444) but did not reach statistical significance (Table 2 ).

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