Nuclear Binding Protein 2/Nesfatin-1 Affects Trophoblast Cell Fusion during Placental Development via the EGFR-PLCG1-CAMK4 Pathway.

Meanwhile, the level of E-cadherin protein similarly showed a trend of steady increase, peaking on day 19.5 ( Figure 1 c).

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Placental NUCB2 mRNA levels showed a clear trend of increasing and then decreasing from gestation days 14.5 to 19.5, with NUCB2 mRNA levels on gestation day 17.5 being significantly higher than that those on gestation days 14.5 and 19.5, and reaching the lowest level on gestation day 19.5 ( Figure 1 d).

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