Somatic mutations show no clear association with red blood cell or human leukocyte antigen alloimmunization in de novo or therapy-related myelodysplastic syndrome.

Discussion: While JAK2 specific mutations were enriched among RBC alloimmunized patients, this association failed to reach statistical significance in our single-center cohort.

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Though we observed a trend toward greater anti-RBC alloimmunization prevalence in patients with JAK2 mutations, it did not reach statistical significance.

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