Efficacy of biologically-directed daylight therapy on sleep and circadian rhythm in Parkinson's disease: a randomised, double-blind, parallel-group, active-controlled, phase 2 clinical trial.

The MDS-UPDRS motor (III) ( Table S1 ) mean score showed a trend of improvement in the Enhanced Mel group [−6.43 (−12.85 to −1.01), p = 0.05].

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There was a phase-advance in DLMO in both groups which did not reach statistical significance between groups at any time-point.

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