Multiple roles of baicalin and baicalein in the regulation of colorectal cancer.

Additionally, there has been a marked trend towards a younger age group for this disease in recent years and Significant increase in the incidence of colorectal cancer before the age of 50 years, especially in countries with high socio-demographic populations ( Dekker et al., 2019 ; GBD, 2019 Colorectal Cancer Collaborators, 2022 ; Sinicrope, 2022 ).

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It was accompanied by the downregulation of PI3K, AKT, and GSK-3β mRNA, However, this decrease did not reach statistical significance upon the introduction of LY294002, a PI3K pathway inhibitor.

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