A strong trend towards the downregulation of genes related to neurodevelopment, including synaptic transmission and CNS developmental pathways, and cell signalling, was found, in addition to altered mRNA expression of methylation-related enzymes.
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Altered N6-Methyladenosine Modification Patterns and Transcript Profiles Contributes to Cognitive Dysfunction in High-Fat Induced Diabetic Mice.
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The sentences
In contrast, genes associated with T2DM, obesity, and cancer showed a trend toward downregulation of m6A methylation and upregulation of mRNA expression.