Short-Term Effects of Botulinum Toxin-A Injection on the Medial Gastrocnemius Histological Features in Ambulant Children with Cerebral Palsy: A Longitudinal Pilot Study.

A shift toward a slower fiber profile with a relative increase in type I (+6%) and IIa (+24%) proportion and a decrease in type IIx proportion (−45%, p = 0.06) was visible 3 months after BoNT-A injection compared with the baseline, but this change did not reach statistical significance.

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Compared with the baseline, the absolute fiber cross-sectional area (fCSA) of all fiber types decreased by 14% 3 months after BoNT-A injection, mainly because of a reduction in the absolute fCSA of the type IIa fiber (−15%); however, these changes failed to reach statistical significance ( Figure 3 , Table 2 ).

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