Integrative Analyses of Tumor and Peripheral Biomarkers in the Treatment of Advanced Renal Cell Carcinoma.

However, although analyses in the A+Ax arm showed similar trends, no associations with PFS were observed in peripheral blood, though a strong trend toward longer PFS was observed with a higher fraction of infiltrating T cells in the pretreatment tumor in the A+Ax arm but not in the sunitinib arm ( Fig. 2A ).

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Of the 32 proteins analyzed, only cytokines and chemokines with levels above the lower limit of quantitation (LLOQ) for a significant fraction of patients who also showed a trend or association with response are shown here.

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