Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.

Additionally, an interaction approaching significance ( p = 0.054) was present seven days into bed rest, where participants who did not show signs of SANS exhibited reduced DTI-ALPS index from pre-bed rest, while SANS participants displayed an elevation in DTI-ALPS index (Fig. 2 and Supplementary Table 1 ).

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Additionally, across all participants, there was an effect of time in decreasing median MV-PVS volume that approached significance ( p = 0.078) with bed rest.

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