Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets.

PLoS One · 2024 · PMC10911599 · PMID 38437228

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0.0600

closest p · 1.2× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

In addition, PF 05105679 alone slightly decreased the ADP-induced platelet aggregation at 37°C, but this effect also did not reach statistical significance ( Fig 5A , p = 0.06).

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approaching significancep = 0.07so close (0.05 < p ≤ 0.1)

At 22°C the addition of menthol tended to increase calcium levels compared to the vehicle (approaching significance p = 0.07, Fig 6B ), however, this effect was absent at 37°C ( p = 0.17).

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