The Association of Physical Activity with Glaucoma and Related Traits in the UK Biobank.

A similar positive association was identified between increasing quartile of time spent in total PA and thicker mGCIPL: participants in the second highest and highest quartile (i.e., quartiles 3 and 4) showed thicker mGCIPL by +0.18 μm ( P = 0.016) and +0.16 μm ( P = 0.029), respectively, compared with those in the lowest quartile, with a significant trend ( P = 0.005 for trend).

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Sensitivity analyses additionally adjusting for caffeine ( Table S6 , available at www.aaojournal.org ) and excluding participants with Alzheimer’s disease, Parkinson’s disease, or multiple sclerosis ( Table S7 , available at www.aaojournal.org ) resulted in very modest attenuation of the associations with mGCIPL, although they all remained nominally significant.

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