Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.

However, two variants on chromosome 17 showed a trend toward significance in the Sierra Leone cohort (Table 1 and Extended Data Fig. 2e ). rs73397758 ( P = 5.5 × 10 −8 , odds ratio (OR) = 9.16) is ~350 KB (kilobase pairs) downstream of the gene CASC17 , a long non-coding RNA named for a genetic association with prostate cancer 37 , and 570 KB upstream of KCNJ2 , a potassium inwardly rectifying channel 38 . rs143130878 ( P = 1.1 × 10 −7 , OR = 6.87) resides 62,472 base pairs downstream of the gene CCT6B 39 , which is a member of the molecular chaperone (TRiC) family that has been shown to regulate the replication of arenaviruses, including LASV 40 .

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However, two variants on chromosome 17 showed a trend toward significance in the Sierra Leone cohort (Table 1 and Extended Data Fig. 2e ). rs73397758 ( P = 5.5 × 10 −8 , odds ratio (OR) = 9.16) is ~350 KB (kilobase pairs) downstream of the gene CASC17 , a long non-coding RNA named for a genetic association with prostate cancer 37 , and 570 KB upstream

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We further note that rs73404538 is nominally significant in the Sierra Leone susceptibility GWAS ( P = 0.039, OR = 0.71) and in a meta-analysis of the Nigeria and Sierra Leone susceptibility GWASs ( P = 0.021) with a concordant direction of effect (Extended Data Table 4 ).

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All three variants that were trending toward significance in the susceptibility GWAS are of low frequency (Table 1 ) and will require larger sample sizes for validation.

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