Phosphodiesterases Mediate the Augmentation of Myogenic Constriction by Inhibitory G Protein Signaling and is Negatively Modulated by the Dual Action of RGS2 and 5.

In contrast, only in WT mice showed a decreasing trend in EDV following L-NAME administration.

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In contrast, UA lacking Rgs5 showed a trend toward enhanced forskolin-induced cAMP generation.

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In Rgs5 −/− UA, basal PDE activity trended higher relative to WT level; however, the difference did not reach statistical significance ( Figure 8B ).

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