Azathioprine/cyclosporin A and prednisolone treatment showed a trend for reduced NAbs at day 85 compared with no IS; however, this was not significant (Supplementary Fig.
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Prednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques.
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By quantitative image analysis, the mean levels of hFVIII hybridization signal in animals in the prednisolone group were higher than in the no IS and azathioprine/cyclosporin A groups, although this did not reach statistical significance (Supplementary Fig.